Dr. Jean Orelien, CEO My passion is helping solve problems at the intersection of health, science, and technology. In other words, problems for which we can use science and technology to improve lives. With ScitoVation, our… Read more »

data system

Patrick McMullen, Director of Computational Toxicology I have often joked that as a computational biologist in an applied field that has been slow to embrace bioinformatics, it is my goal… Read more »

As an advocate in PBPK modeling for risk assessment, I want to share with you the latest guidance from the Organization of Economic Cooperation and Development (OECD). I write a lot of reports on PBPK models for clients, and it makes a huge difference… Read more »

by Jeff Fisher This story begins in 1998 when I reviewed a technical document for the chemical perchlorate, now known to be widely distributed in the environment on earth and has been… Read more »

In the past, dose responses results from in life toxicology studies were used to estimate no observed effect levels (NOELs) and more recently benchmark doses (BMDs). These observational studies of apical endpoints were frequently followed up by mechanistic… Read more »

Melvin E. Andersen Biomarkers of exposure can be measured at lower and lower levels due to advances in analytical chemistry. Using these highly sensitive methods, some epidemiology studies report associations between plasma and urinary biomarkers… Read more »

Last week, my colleague, Scott Slattery, presented a webinar on in vitro inhalation point-of-contact toxicity testing with vapors. It brought me back to when I started working with Scott last year on this project. As a physiologically based pharmacokinetic modeler, the only time I worked in a lab…

Using Physiologically Based Pharmacokinetic (PBPK) Modeling and In vitro to In vivo Extrapolation (IVIVE) in Risk Assessment

Chemical discovery and risk assessment

To kick off a new year and decade, we assessed ScitoVation’s current and prospective positioning in the risk assessment community.  As part of that process, the leadership team reviewed our… Read more »

By Mel Andersen, Ph.D., Senior Program Advisor It’s a grand time to be a toxicologist committed to using non-animal based biological and computational methods to assess the safety of chemicals and chemical products for human populations.  My toxicology career… Read more »