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In vitro methods capable of describing systemic effects of chemicals require use of multiple tissue types connected with a common perfusate. This arrangement allows integration of absorption, metabolism and toxicity data over extended times in vitro and provides a novel, animal-free tool for chemical, cosmetic, and pharmaceutical testing. In order to test this, a study on the uptake and distribution of acetaminophen (APAP) in a human dynamic multi-organ plate (HuDMOP™) with three tissue surrogates arranged in series: first…Read more »

Chemical risk assessment is moving away from animal testing replacing it with computational and in vitro approaches in risk assessment. Dosimetry, by determining the amounts and key rates for distribution of a chemical in the body, is essential for the use of new approach methodologies in risk-based decision making. Use of models such as high-throughput in vitro to in vivo extrapolation (HT-IVIVE) has…Read more »

Over the past three years we have been developing the population life-course exposure to health effects model (PLETHEM) – the open source R package that is designed to provide tools that can be used to bridge the source-to-outcome continuum. Pharmacokinetic modeling is becoming increasingly important in chemical safety decision making, with applications in prioritizing risk assessment by establishing margins of exposure for chemicals and extrapolating hazard across different ages, population cohorts, or occupational classes. As a part of our effort to provide the community with…Read more »

Safety assessment strategies that rely on testing species-relevant cells in vitro are advancing, yet there are currently no in vitro alternatives for hepatotoxicity testing accepted by regulators. An organotypic rat model, capable of predicting rat in vivo responses to hepatotoxicants, will provide an affordable and ethical alternative to in vivo rat models currently utilized. An ideal in vitro liver model for hepatotoxicity testing would include hepatocytes and the non-parenchymal cells (NPCs) (i.e., hepatic stellate cells, Kupffer cells, and liver sinusoidal endothelial cells), and would support…Read more »

Gene expression profiling is emerging as a viable way to evaluate mode of action and points of departure and has the potential to drastically reduce testing costs and product development time. The first steps of using transcriptional responses as a basis of safety assessment are being taken. However, several important considerations remain unresolved, including how to translate expression changes into adverse outcome pathways or other definitions of mode of action…Read more »

As part of its annual Clarenburg Lecture Series, the College of Veterinary Medicine will host Melvin “Mel” Andersen at 4 p.m. Tuesday, Oct. 8, in the Mara Conference Center on… Read more »

 ScitoVation, pioneers in chemical safety assessment, and a rapidly growing life sciences solution company based in the Research Triangle Park, North Carolina, today announced the appointment of Shiloh J. Barfield… Read more »

ScitoVation launched its new Collaborative Partnering Program (CPP) designed to engage industry consultants to promote the use of 21st-century safety assessment methods and new alternative methods (NAMS) with their clients.… Read more »

Dr. Moreau – Manager of the company’s PBPK (Physiologically based pharmacokinetic modeling) division has been selected to receive the 2019 Health Products, and Food Branch Assistant Deputy Minister’s Award for… Read more »