Pharmacokinetics

PBPK Modeling

Physiologically Based Pharmacokinetic (PBPK) Modeling is a predictive tool to estimate how compounds are absorbed, distributed, metabolized, and excreted.

With PBPK Modeling, we help our clients:

  • Predict exposure from one species to another
  • Predict exposure for vulnerable populations, such as children, the elderly, or those working in specific occupations
  • Predict concentration in blood or tissue from dermal exposure using oral exposure data
  • Use high dosage exposure to predict concentration in blood and tissue for exposure at lower dose
  • Estimate population daily exposure intakes that are consistent with blood or urine measures found in biomonitoring surveys

We provide value because:

  • We are experts at using software tool PLETHEM which we developed in collaboration with U.S. EPA
  • We can perform IVIVE analysis
  • We also have in vitro capability to provide input data for PBPK models