PBPK Modeling
Physiologically Based Pharmacokinetic (PBPK) Modeling is a predictive tool to estimate how compounds are absorbed, distributed, metabolized, and excreted.
With PBPK Modeling, we help our clients:
- Predict exposure from one species to another
- Predict exposure for vulnerable populations, such as children, the elderly, or those working in specific occupations
- Predict concentration in blood or tissue from dermal exposure using oral exposure data
- Use high dosage exposure to predict concentration in blood and tissue for exposure at lower dose
- Estimate population daily exposure intakes that are consistent with blood or urine measures found in biomonitoring surveys
We provide value because:
- We are experts at using software tool PLETHEM which we developed in collaboration with U.S. EPA
- We can perform IVIVE analysis
- We also have in vitro capability to provide input data for PBPK models
